SPF or Sender Policy Framework figthts e-mail forgery in SMTP transaction. It prevents unauthorized people from forging email addresses. When users enable SPF, a DNS TXT record is created for DNS zone hosting this domain. It defines what IP's can be used to send mail from this domain. On receiving e-mail from user's domain, recipient, providing SPF is enabled on their side, can check if it indeed was sent from the IP listed in this DNS record.
SRS or Sender Rewriting Scheme is a mechanism to rewrite sender addresses when a mail is forwarded in such a way that mail forwarding continues to work in an SPF compliant world. When you add SRS, then srs qmail parameters will be included on all mail servers, also base64 secret key used in the SRS address cipher will be generated. You can include mailSRS cron in the Background Job Manager to regenerate secret key every month.